Benzo [e] [1,3] oxazin-4-one derivatives as phosphoinositide 3-kinase inhibitors

Abstract

Compounds of formula (I): wherein: W is O, N—H, N-alkyl, N-alkenyl, N-alkynyl, N-aryl, N-heteroaryl or S; each X is independently CH or N; Ris formula (b) or Ris H, alkyl, NH, OH, =0 or halogen; each A and B are independently CH or N; D is NHR; Ris H, alkyl, —C(O)-alkyl. —C(O)—NH, —C(O)—NH-alkyl, —SO-alkyl, —SO—NHor —SO—NH-alkyl; Ris aryl substituted with at least one nitrogen-containing group or Ris a nitrogen-containing heteroaryl, cycloalkyl substituted with a nitrogen-containing group, nitrogen-containing cycloalkyl, C-Cmono alkylamino, CCbis alkylamino, CCacylamino, C-Caminoalkyl, mono (CCalkyl)amino C-Calkyl, bis (CCalkyl)amino CCalkyl, C-C-acylamino or CCalkynyl-NR, Ris H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, halogen, O-alkyl, NH-alkyl, N-dialkyl, —C(O)—R, —C(O)—NH, —C(O)—NH—R, —SO—R, —SO—NH, —SO—NH—R, NH-acyl, NH-sulfonyl, NR-acyl, NR-sulfonyl, N—C(O)—NH—R, N—SO—NH—R, N—C(O)—NRRor N—SO—NRR; and Ris alkyl, aryl or heteroaryl, are useful as PI3K inhibitors and are useful in therapy.