The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Oct. 26, 2012
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Andras Horvath, Turnhout, BE;
Stijn Wuyts, Oostham, BE;
Dominique Paul Michel Depré, Hamme-Mille, BE;
Wouter Louis J. Couck, Zomergem, BE;
Jozef Ludo Jan Cuypers, Vossellar, BE;
Syuzanna Harutyunyan, Groningen, NL;
Gregory Fabien Sebastian Binot, Monthey, CH;
Janssen Pharmaceuticals, Inc., Titusville, NJ (US);
Abstract
The present invention relates to an improved process for preparing (2R,3aR,10Z,11aS,2aR,14aR)-cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxylic acid, 2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-10(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, ethyl ester. This compound is an intermediate in the overall synthesis route of the macrocyclic compound TMC 435. TMC 435 is an inhibitor of NS3/4A protease which plays an important role in the replication of the hepatitis C virus.