The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Oct. 24, 2008
Takanori Kubo, Hiroshima, JP;
Hideki Ohba, Tosu, JP;
Hidekazu Toyobuku, Osaka, JP;
Hirotake Hayashi, Osaka, JP;
Takanori Kubo, Hiroshima, JP;
Hideki Ohba, Tosu, JP;
Hidekazu Toyobuku, Osaka, JP;
Hirotake Hayashi, Osaka, JP;
National Institute of Advanced Industrial Science and Technology, Tokyo, JP;
Otsuka Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
An object of the present invention is to provide a novel double-stranded RNA that has high nuclease resistance and high cellular uptake efficiency, and that is capable of producing an excellent RNA interference effect. The present invention provides a lipid-modified double-stranded RNA comprising a sense strand having a nucleotide sequence complementary to a target sequence, and an antisense strand having a nucleotide sequence complementary to the sense strand, the double-stranded RNA being capable of inhibiting the expression of the target gene, the sense strand having a lipid linked to at least one of the first to sixth nucleotides from the 5' end side directly or via a linker.