The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Apr. 19, 2013
Applicant:
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Inventors:
Simone Budow, Tecklenburg, DE;
Ping Ding, Muenster, DE;
Dieter Heindl, Paehl, DE;
Alfons Nichtl, Hohenpeissenberg, DE;
Frank Seela, Osnabrueck, DE;
Assignee:
Roche Diagnostics Operations, Inc., Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/00 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C07H 21/02 (2013.01);
Abstract
An oligonucleotide-solid phase conjugate, wherein the solid phase is thiophilic and the oligonucleotide comprises at least one thiooxonucleobase according to Formula I, wherein X is CH or N, R1 is H or NH2, --- indicates a covalent bond, and said oligonucleotide is bound to said solid phase via the sulfur atom of said thiooxonucleotide. Also disclosed are methods for producing such conjugate as well as various uses for such oligonucleotide metal conjugate.