The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Sep. 24, 2012
Applicant:
The University of Toledo, Toledo, OH (US);
Inventors:
Zi-Jian Xie, Saline, MI (US);
Joseph I. Shapiro, Toledo, OH (US);
Jiang Tian, Perrysburg, OH (US);
Zhichuan Li, Williamsville, NY (US);
Assignee:
The University of Toledo, Toledo, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); C07K 14/47 (2006.01); A61K 38/45 (2006.01); A61K 38/46 (2006.01); C07K 7/08 (2006.01); G01N 33/573 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4703 (2013.01); A61K 38/45 (2013.01); A61K 38/46 (2013.01); C07K 7/08 (2013.01); C07K 14/4705 (2013.01); G01N 33/573 (2013.01); C12Y 306/03009 (2013.01); C12Y 207/10002 (2013.01);
Abstract
A method for regulating Src and its downstream signaling pathway which includes binding between Src and Na+/K+-ATPase is disclosed. The Na+/K+-ATPase/Src complex is a functional receptor for cardiotonic steroids such as ouabain. Also disclosed are Src inhibitors or activators which include either Na+/K+-ATPase or Src that interfere with the interaction between the Na/K-ATPase and Src, act via a different mechanism from ATP analogs, and is pathway (Na+/K+-ATPase) specific.