The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Apr. 20, 2011
Hideyoshi Harashima, Hokkaido, JP;
Hidetaka Akita, Hokkaido, JP;
Mohammad Shaheen Sharif, Hokkaido, JP;
Takashi Nakamura, Hokkaido, JP;
Soichiro Ishii, Hokkaido, JP;
Shiroh Futaki, Kyoto, JP;
Hideyoshi Harashima, Hokkaido, JP;
Hidetaka Akita, Hokkaido, JP;
Mohammad Shaheen Sharif, Hokkaido, JP;
Takashi Nakamura, Hokkaido, JP;
Soichiro Ishii, Hokkaido, JP;
Shiroh Futaki, Kyoto, JP;
National University Corporation Hokkaido University, Hokkaido, JP;
Abstract
A lipid membrane structure for delivering a substance into a nucleus of a cell, wherein lipid membrane is modified with (a) a polypeptide comprising the amino acid sequence of SEQ ID NO: 1, and/or (b) a polypeptide consisting of an amino acid sequence comprising the amino acid sequence of SEQ ID NO: 1, but including deletion and/or substitution and/or insertion of one or several amino acid residues, and having an activity of promoting migration of the lipid membrane structure into a nucleus of a cell, which can efficiently deliver a nucleic acid into a nucleus of an immunocyte such as dendritic cell.