The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2015

Filed:

Apr. 28, 2014
Applicants:

Pola Pharma Inc., Tokyo, JP;

Nihon Nohyaku Co., Ltd., Tokyo, JP;

Inventors:

Takaaki Masuda, Kanagawa, JP;

Hiroshi Yamaguchi, Tokyo, JP;

Assignees:

Pola Pharma Inc., Tokyo, JP;

Nihon Nohyaku Co., Ltd., Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4178 (2006.01); C07D 409/06 (2006.01); G01N 30/02 (2006.01);
U.S. Cl.
CPC ...
G01N 30/02 (2013.01); A61K 31/4178 (2013.01); G01N 2030/027 (2013.01);
Abstract

Disclosed is a method of evaluating stability of a pharmaceutical preparation containing luliconazole. The method includes measuring an amount of production of an SE form of luliconazole represented by following formula (2), an amount of production of a Z form of luliconazole represented by following formula (3) and an amount of production of an amide form of luliconazole represented by following formula (1) after storage under a severe condition or an accelerated condition, and judging that the stability of the pharmaceutical preparation is high if each of the amount of production of the SE form, the amount of production of the Z form and the amount of production of the amide form is not more than 5% by weight with respect to a compounded amount of luliconazole.


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