The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2015

Filed:

May. 16, 2011
Applicants:

Jacqueline D. Hicks, Scotch Plains, NJ (US);

Tesfaye Biftu, Freehold, NJ (US);

Ping Chen, Edison, NJ (US);

Xiaoxia Qian, New York, NY (US);

Robert R. Wilkening, Maplewood, NJ (US);

Inventors:

Jacqueline D. Hicks, Scotch Plains, NJ (US);

Tesfaye Biftu, Freehold, NJ (US);

Ping Chen, Edison, NJ (US);

Xiaoxia Qian, New York, NY (US);

Robert R. Wilkening, Maplewood, NJ (US);

Assignee:

Merck Sharp & Dohme Corp., Rahway, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/78 (2006.01); A61K 31/425 (2006.01); C07D 413/00 (2006.01); C07D 498/00 (2006.01); C07D 417/00 (2006.01); C07D 513/00 (2006.01); C07D 271/12 (2006.01); C07D 285/14 (2006.01); C07D 487/04 (2006.01); C07D 471/04 (2006.01); A61K 31/4162 (2006.01); A61K 31/437 (2006.01); A61K 31/4439 (2006.01); A61K 31/506 (2006.01); A61K 31/519 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 471/04 (2013.01); A61K 31/4162 (2013.01); A61K 31/437 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 31/519 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention is directed to novel amino-substituted seven-membered heterocyclic compounds of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.


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