The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Nov. 27, 2012
Applicant:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Inventors:
Shaomeng Wang, Saline, MI (US);
Hacer Karatas, Ann Arbor, MI (US);
Yali Dou, Ann Arbor, MI (US);
Elizabeth Townsend, Ann Arbor, MI (US);
Denzil Bernard, Ann Arbor, MI (US);
Fang Cao, Ann Arbor, MI (US);
Assignee:
The Regents of the University of Michigan, Ann Arbor, MI (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/12 (2006.01); A61P 35/00 (2006.01); C07K 5/12 (2006.01); A61K 45/00 (2006.01); A61N 5/10 (2006.01); C07D 255/02 (2006.01); C07K 5/02 (2006.01); C07K 5/09 (2006.01); C07K 5/103 (2006.01); C07K 5/11 (2006.01); C07K 5/062 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 5/126 (2013.01); A61K 38/12 (2013.01); A61K 45/00 (2013.01); A61N 5/10 (2013.01); C07D 255/02 (2013.01); C07K 5/123 (2013.01); C07K 5/0207 (2013.01); C07K 5/021 (2013.01); C07K 5/0215 (2013.01); C07K 5/0815 (2013.01); C07K 5/101 (2013.01); C07K 5/1019 (2013.01); C07K 5/06034 (2013.01); A61K 45/06 (2013.01); A61N 2005/1098 (2013.01);
Abstract
Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.