The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Oct. 27, 2008
Applicants:
Richard D. Dimarchi, Carmel, IN (US);
Bin Yang, Bloomington, IN (US);
Chenguang Ouyang, Bloomington, IN (US);
Inventors:
Richard D. Dimarchi, Carmel, IN (US);
Bin Yang, Bloomington, IN (US);
Chenguang Ouyang, Bloomington, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/605 (2006.01); C07K 7/02 (2006.01); A61K 38/26 (2006.01); A61K 38/16 (2006.01); A61K 38/22 (2006.01); A61P 3/04 (2006.01); A61P 3/10 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); A61K 38/16 (2013.01); C07K 7/02 (2013.01); A61K 38/22 (2013.01); A61K 38/26 (2013.01); A61K 38/00 (2013.01);
Abstract
Glucagon analogs are disclosed that exhibit both glucagon antagonist and GLP-1 agonist activity. In one embodiment, the glucagon antagonist/GLP-1 agonist comprises a modified amino acid sequence of native glucagon, in which the first one to five N-terminal amino acids of native glucagon is deleted and in which the alpha helix is stabilized.