The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Dec. 14, 2006
Antje Gupta, Wiesbaden, DE;
Maria Bobkova, Wiesbaden, DE;
Anke Tschentscher, Eltville-Hattenheim, DE;
Antje Gupta, Wiesbaden, DE;
Maria Bobkova, Wiesbaden, DE;
Anke Tschentscher, Eltville-Hattenheim, DE;
Cambrex IEP GmbH, Wiesbaden, DE;
Abstract
In a process for the enantioselective enzymatic reduction of a hydroxy ketone of general formula I wherein R=C-Calkyl and R=—Cl, —CN, —OH, —H or C-Calkyl, into a chiral diol of general formula II wherein Rand Rhave the same meaning as in formula I, the hydroxy ketone is reduced with an oxidoreductase in the presence of NADH or NADPH as a cofactor, whereina) the hydroxy ketone is provided in the reaction at a concentration of ≧50 g/l,b) the oxidized cofactor NAD or NADP having formed is regenerated continuously by oxidation of a secondary alcohol of general formula RRCHOH, wherein R, Rindependently represent hydrogen, branched or unbranched C-C-alkyl and C≧3, andc) the reduction of the hydroxy ketone and the oxidation of the secondary alcohol are catalyzed by the same oxidoreductase.