The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Jun. 29, 2012
Nan Lin, St. Louis, MO (US);
Henry J. George, St. Louis, MO (US);
Joaquina Mascarenhas, St. Louis, MO (US);
Trevor N. Collingwood, St. Louis, MO (US);
Kevin J. Kayser, St. Louis, MO (US);
Katherine Achtien, St. Louis, MO (US);
Nan Lin, St. Louis, MO (US);
Henry J. George, St. Louis, MO (US);
Joaquina Mascarenhas, St. Louis, MO (US);
Trevor N. Collingwood, St. Louis, MO (US);
Kevin J. Kayser, St. Louis, MO (US);
Katherine Achtien, St. Louis, MO (US);
Sigma-Aldrich Co. LLC, St. Louis, MO (US);
Abstract
The present invention provides non-human mammalian cell lines that are deficient in CMP-Neu5Ac hydroxylase (Cmah) and/or glycoprotein alpha-1,3-galactosyltransferase (Ggta1). Also provided are methods for using the cells disclosed herein for producing recombinant proteins with human-like patterns of glycosylation.