The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 17, 2015

Filed:

Aug. 16, 2013
Applicant:

Nioxx Llc, Dickinson, TX (US);

Inventors:

Cheng-Shing Chen, Taichung, TW;

Ferid Murad, McLean, VA (US);

Kenneth A Smith, Houston, TX (US);

William A Seitz, Dickinson, TX (US);

William J Merrell, Galveston, TX (US);

Alexandru T Balaban, Galveston, TX (US);

Assignee:

Nioxx LLC, Dickinson, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/194 (2006.01); A61K 33/00 (2006.01); A61K 47/36 (2006.01); A61K 9/14 (2006.01); A01N 59/14 (2006.01); A61K 9/70 (2006.01); A61K 31/341 (2006.01); A61K 33/22 (2006.01); A61K 9/06 (2006.01); A61K 9/50 (2006.01); A61K 31/19 (2006.01); A61K 31/375 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 9/14 (2013.01); A01N 59/14 (2013.01); A61K 9/70 (2013.01); A61K 33/00 (2013.01); A61K 31/341 (2013.01); A61K 33/22 (2013.01); A61K 31/194 (2013.01); A61K 47/36 (2013.01); A61K 9/06 (2013.01); A61K 9/5047 (2013.01); A61K 9/5052 (2013.01); A61K 31/19 (2013.01); A61K 31/375 (2013.01); A61K 45/06 (2013.01);
Abstract

Methods and compositions are provided for generating and applying long-lasting therapeutic nitric oxide (NO) gas from the reaction of water-soluble chemical reactants microencapsulated in polymer matrices. In some applications the microencapsulated reactants are introduced in an aqueous gel, and in other applications they are introduced to the area of therapy either directly or in a medical device such as a therapeutic pad or dressing. In some applications, the microencapsulated chemical precursors are maintained in close physical proximity to one another in a limited volume, and using a limited amount of solvent residing within that same volume to extract and process the chemical precursors to form NO.


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