The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Jan. 25, 2011
Konstantin Ichtchenko, Brooklyn, NY (US);
Philip A. Band, West Orange, NJ (US);
Konstantin Ichtchenko, Brooklyn, NY (US);
Philip A. Band, West Orange, NJ (US);
New York University, New York, NY (US);
Abstract
This invention relates to isolatedpropeptides and neurotoxins, isolated nucleic acid molecules encodingpropeptides and neurotoxins, methods of expression, treatment methods, and methods of detecting neurotoxin trafficking. The isolatedpropeptides have a light chain region; a heavy chain region, where the light and heavy chain regions are linked by a disulfide bond; an intermediate region connecting the light and heavy chain regions and comprising a highly specific protease cleavage site; and an S6 peptide sequence according to SEQ ID NO:2 positioned upstream from, but not attached directly to, the N-terminus of the neurotoxin propeptide at the light chain region to enable site specific attachment of cargo.