The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Nov. 18, 2011
Thorsten Steinberg, Mannheim, DE;
Wilfried Weber, Freiburg, DE;
Raphael Guebeli, Buetschwil, CH;
Pascal Tomakidi, Freiburg, DE;
Dougal Laird, Freiburg, DE;
Thorsten Steinberg, Mannheim, DE;
Wilfried Weber, Freiburg, DE;
Raphael Guebeli, Buetschwil, CH;
Pascal Tomakidi, Freiburg, DE;
Dougal Laird, Freiburg, DE;
Universitaetsklinikum Freiburg, Freiburg, DE;
Albert-Ludwigs-Universitaet Freigburg, Freiburg, DE;
Abstract
The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components.