The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Mar. 14, 2003
Klaus Pfizenmaier, Tiefenbronn, DE;
Harald Wajant, Leinfelden-Echterdingen, DE;
Dieter Moosmayer, Berlin, DE;
Thomas Wuest, Dietikon, CH;
Klaus Pfizenmaier, Tiefenbronn, DE;
Harald Wajant, Leinfelden-Echterdingen, DE;
Dieter Moosmayer, Berlin, DE;
Thomas Wuest, Dietikon, CH;
BioNTech AG, , DE;
Abstract
Subject matter of the invention are antibody-cytokine fusion proteins having proapoptotic and immune modulating properties, but wherein the cytokine moiety a priori has a bioactivity which is very low or restricted to certain receptor subtypes. These reagent exert their full biological activity via the corresponding cytokine receptor(s) only after antibody-mediated binding of the fusion protein to a specific cell membrane-expressed target molecule. By suitable choice of the antibody specificity, the cytokine activity is directed to the tissue, e.g. tumor tissue, to be treated, and a therapeutic agent can be produced being specifically designed/optimized for the respective indication/tumor entity.