The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Mar. 14, 2013
Oncomed Pharmaceuticals, Inc., Redwood City, CA (US);
Austin L. Gurney, San Francisco, CA (US);
Timothy Charles Hoey, Hillsborough, CA (US);
Edward Thein Htun van der Horst, Palo Alto, CA (US);
Aaron Ken Sato, Burlingame, CA (US);
Yuan Ching Liu, Fremont, CA (US);
Maureen Fitch Bruhns, San Mateo, CA (US);
John A. Lewicki, Los Gatos, CA (US);
OncoMed Pharmaceuticals, Inc., Redwood City, CA (US);
Abstract
The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.