The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Mar. 13, 2013
Xizhong Huang, Southborough, MA (US);
Malte Peters, Basel, CH;
Karl Maria Schumacher, Darmstadt, DE;
Zhu Alexander Cao, Acton, MA (US);
Jennifer Lorraine Gansert, Simi Valley, CA (US);
David Dong Eun Chang, Calabasas, CA (US);
Xizhong Huang, Southborough, MA (US);
Malte Peters, Basel, CH;
Karl Maria Schumacher, Darmstadt, DE;
Zhu Alexander Cao, Acton, MA (US);
Jennifer Lorraine Gansert, Simi Valley, CA (US);
David Dong Eun Chang, Calabasas, CA (US);
Novartis AG, Basel, CH;
Amgen, Inc., Thousand Oaks, CA (US);
Abstract
The present invention relates to a pharmaceutical combination comprising an alpha-isoform specific phosphatidylinositol 3-kinase inhibitor compound, such as (S)-Pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide), or pharmaceutically acceptable salt thereof, and an insulin-like growth factor-1 receptor (IGF1R) inhibitor (e.g., the IGF1R inhibitor ANTIBODY A, or a variant or derivative thereof), a pharmaceutical composition comprising such combination, methods for treating cancer comprising administration of therapeutically effective amounts of such inhibitors to a subject in need thereof, and uses of such combination for the treatment of cancer.