The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
May. 17, 2011
Applicants:
Makoto Kaneda, Ina, JP;
Yoshihiro Fujii, Ina, JP;
Yoshihiro Hayata, Ina, JP;
Yoshiro Kishi, Ina, JP;
Ichiro Yahara, Ina, JP;
Inventors:
Makoto Kaneda, Ina, JP;
Yoshihiro Fujii, Ina, JP;
Yoshihiro Hayata, Ina, JP;
Yoshiro Kishi, Ina, JP;
Ichiro Yahara, Ina, JP;
Assignee:
Medical & Biological Laboratories Co., Ltd., Aichi, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); A61K 39/395 (2006.01); C07K 16/00 (2006.01); C07K 16/18 (2006.01); C07K 16/24 (2006.01); C12N 15/00 (2006.01); C12N 15/09 (2006.01); C12N 15/11 (2006.01); C12N 15/13 (2006.01); C12N 15/63 (2006.01); C12N 5/10 (2006.01); C12N 5/16 (2006.01); C12N 5/18 (2006.01); C12N 5/20 (2006.01); C12N 5/22 (2006.01); C12N 5/24 (2006.01); C12N 5/26 (2006.01); C12N 5/28 (2006.01); C07K 16/22 (2006.01); C07K 14/495 (2006.01);
U.S. Cl.
CPC ...
C07K 16/22 (2013.01); C07K 14/495 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01);
Abstract
It has been found out that among antibodies showing reactivity with wild type TGF-α, antibodies less reactive with G79A-substituted TGF-α have an excellent growth-suppressing effect on cancer cells having a mutated Ras gene. Further, it has been found out that most of these antibodies have an activity of inhibiting EGFR tyrosine phosphorylation and/or an induction-suppressing activity on vascular endothelial cells.