The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Dec. 17, 2010
Molly Sandra Shoichet, Toronto, CA;
Tasneem Zahir, Mississauga, CA;
Brian Ballios, Mississauga, CA;
Derek Van Der Kooy, Toronto, CA;
Michael Cooke, Toronto, CA;
Molly Sandra Shoichet, Toronto, CA;
Tasneem Zahir, Mississauga, CA;
Brian Ballios, Mississauga, CA;
Derek Van der Kooy, Toronto, CA;
Michael Cooke, Toronto, CA;
The Governing Council of the University of Toronto, Toronto, Ontario, CA;
Abstract
This invention provides a polymer composition comprising at least one thermal gelling polymer and at least one anionic polymer for cell delivery applications. These injectable polymer compositions are shear-thinning, thixotropic and resorbable. More specifically there is described a hyaluronan (HA) and methylcellulose (MC) based thermogelling cell delivery system (HAMC) that promotes cell survival both in vitro and in vivo. Importantly, HAMC (relative to media alone) enhances survival of transplanted stem/progenitor cells in the injured CNS. HAMC provides a minimally-invasive cell delivery strategy where the microenvironment can be further defined and the differentiation and regenerative capacity further explored. This hydrogel system has applications for minimally-invasive cell delivery to other tissues/organs in the body as well.