The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Dec. 13, 2011
Applicants:
Craig M. Meyers, Hummelstown, PA (US);
Samina Alam, Hershey, PA (US);
Inventors:
Craig M. Meyers, Hummelstown, PA (US);
Samina Alam, Hershey, PA (US);
Assignee:
The Penn State Research Foundation, University Park, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/35 (2006.01); C12N 7/00 (2006.01); C07K 14/005 (2006.01); C12N 15/864 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/768 (2013.01); C12N 7/00 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14133 (2013.01); A61K 38/00 (2013.01); C07K 14/005 (2013.01); C12N 2750/14122 (2013.01);
Abstract
According to the invention, parvoviruses such as the adeno-associated virus Type 2 (AAV2) are found to be oncolytic, selectively mediating apoptosis in cancer cells and their precursors, while leaving healthy cells intact. The invention also includes a method of killing cancer and other neoplastic and preneoplastic cells by administrating to said cells the AAV2 proteins Rep78 or Rep 68, expression constucts encoding the same, or pharmaceutical compositions comprising the same.