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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8980241 B1

PDFFull Text
Date of Patent:
Mar. 17, 2015

Filed:

Dec. 04, 2008

Polymerized cyclic nitroxide radical compound and use thereof

Applicants:

Yukio Nagasaki, Tsukuba, JP;

Toru Yoshitomi, Tsukuba, JP;

Hirofumi Matsui, Tsukuba, JP;

Aki Hirayama, Tsuchiura, JP;

Takashi Mamiya, Tsukuba, JP;

Akira Matsumura, Tsukuba, JP;

Kensuke Suzuki, Tsukuba, JP;

Hideo Tsurushima, Tsukuba, JP;

Aiki Marushima, Tsukuba, JP;

Kazuko Toh, Tsukuba, JP;

Daisuke Miyamoto, Nobeoka, JP;

Inventors:

Yukio Nagasaki, Tsukuba, JP;

Toru Yoshitomi, Tsukuba, JP;

Hirofumi Matsui, Tsukuba, JP;

Aki Hirayama, Tsuchiura, JP;

Takashi Mamiya, Tsukuba, JP;

Akira Matsumura, Tsukuba, JP;

Kensuke Suzuki, Tsukuba, JP;

Hideo Tsurushima, Tsukuba, JP;

Aiki Marushima, Tsukuba, JP;

Kazuko Toh, Tsukuba, JP;

Daisuke Miyamoto, Nobeoka, JP;

Assignee:

University of Tsukuba, Ibaraki, JP;

Attorney:

Wenderoth, Lind & Ponack, L.L.P.

Primary Examiner:

Hasan Ahmed

Int. Cl.
CPC ...
A61K 31/74 (2006.01); C08F 8/30 (2006.01); A23L 1/30 (2006.01); A61K 47/48 (2006.01); A61K 49/08 (2006.01); A61K 49/12 (2006.01); A61K 49/18 (2006.01); A61K 49/20 (2006.01); B82Y 5/00 (2011.01); C08G 65/333 (2006.01); C08G 65/334 (2006.01); C08G 73/10 (2006.01); C08L 71/02 (2006.01); C08L 23/00 (2006.01); C08L 25/00 (2006.01); C08L 71/03 (2006.01); C08L 79/00 (2006.01);
U.S. Cl.
CPC ...
C08F 8/30 (2013.01); A23L 1/30 (2013.01); A61K 47/48176 (2013.01); A61K 47/48215 (2013.01); A61K 49/085 (2013.01); A61K 49/126 (2013.01); A61K 49/1806 (2013.01); A61K 49/1824 (2013.01); A61K 49/20 (2013.01); B82Y 5/00 (2013.01); C08G 65/33396 (2013.01); C08G 65/334 (2013.01); C08G 65/3344 (2013.01); C08G 73/1071 (2013.01); C08G 2261/126 (2013.01); C08L 23/00 (2013.01); C08L 25/00 (2013.01); C08L 71/02 (2013.01); C08L 71/03 (2013.01); C08L 79/00 (2013.01); C08L 2203/02 (2013.01); C08L 2205/05 (2013.01);
Abstract

A method of covalently bonding a cyclic nitroxide radical compound to a hydrophobic block of a specific hydrophylic-phobic block copolymer, and polymerized cyclic nitroxide radical compound copolymerized in this manner, as well as use of such a compound, for instance, in the medical field are provided. The compound demonstrates long term stability in vivo under reductive environment.

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