The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 17, 2015
Filed:
Aug. 25, 2011
David E. Reichert, St. Louis, MO (US);
Paul J. A. Kenis, Champaign, IL (US);
Tobias D. Wheeler, Alameda, CA (US);
Amit V. Desai, Urbana, IL (US);
Dexing Zeng, Pittsburgh, PA (US);
Birce C. Önal, Champaign, IL (US);
David E. Reichert, St. Louis, MO (US);
Paul J. A. Kenis, Champaign, IL (US);
Tobias D. Wheeler, Alameda, CA (US);
Amit V. Desai, Urbana, IL (US);
Dexing Zeng, Pittsburgh, PA (US);
Birce C. Önal, Champaign, IL (US);
The Board of Trustees of the University of Illinois, Urbana, IL (US);
Washington University, St. Louis, MO (US);
Abstract
A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.