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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8975447 B1

PDFFull Text
Date of Patent:
Mar. 10, 2015

Filed:

Mar. 06, 2012

Process for asymetric methylallylation in the presence of a 2,2'-substituted 1,1′-bi-2-naphthol catalyst

Applicants:

Wenjie LI, Hopewell Junction, NY (US);

Zhi-hui LU, Newtown, CT (US);

Chris Hugh Senanayake, Brookfield, CT (US);

Yongda Zhang, Sandy Hook, CT (US);

Inventors:

Wenjie Li, Hopewell Junction, NY (US);

Zhi-Hui Lu, Newtown, CT (US);

Chris Hugh Senanayake, Brookfield, CT (US);

Yongda Zhang, Sandy Hook, CT (US);

Assignee:

Boehringer Ingelheim International GmbH, Ingelheim am Rhein, DE;

Attorneys:

Michael P. Morris

David L. Kershner

Primary Examiner:

Brian J Davis

Int. Cl.
CPC ...
C07C 33/48 (2006.01); C07C 39/38 (2006.01); C07C 29/38 (2006.01); C07C 29/40 (2006.01); C07C 39/14 (2006.01); C07C 37/055 (2006.01); C07C 41/48 (2006.01); C07C 29/143 (2006.01); C07C 37/62 (2006.01);
U.S. Cl.
CPC ...
C07C 39/14 (2013.01); C07C 29/38 (2013.01); C07C 39/38 (2013.01); C07C 37/055 (2013.01); C07C 41/48 (2013.01); C07C 29/143 (2013.01); C07C 37/62 (2013.01); C07B 2200/07 (2013.01);
Abstract

Disclosed are a process and catalysts useful for carrying out asymmetric methlyallylations. The catalysts used in the invention have the formula (IV): wherein X, X, Rand Rare as defined herein. Compounds made by the process of the invention can be used to prepare pharmaceutically active compounds such as 11-β-hydroxysteroid hydrogenase type 1 (11-β-HSD1) inhibitors including 1,3-disubstituted oxazinan-2-ones.

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