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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8975300 B1

PDFFull Text
Date of Patent:
Mar. 10, 2015

Filed:

Dec. 09, 2013

Ketone compounds and compositions for cholesterol management and related uses

Applicant:

Esperion Therapeutics, Inc., Plymouth, MI (US);

Inventors:

Jean-Louis Henri Dasseux, Toulouse, FR;

Carmen Daniela Oniciu, Toulouse, FR;

Assignee:

Esperion Therapeutics, Inc., Ann Arbor, MI (US);

Attorney:

Goodwin Procter LLP

Primary Examiner:

Taofiq A Solola

Int. Cl.
CPC ...
A61K 31/19 (2006.01); C07C 59/353 (2006.01); C07C 49/17 (2006.01); C07C 49/185 (2006.01); C07C 49/215 (2006.01); C07C 49/245 (2006.01); C07C 49/258 (2006.01); C07C 49/507 (2006.01); C07C 49/723 (2006.01); C07C 49/743 (2006.01); C07C 49/747 (2006.01); C07C 49/784 (2006.01); C07C 49/82 (2006.01); C07C 49/86 (2006.01); C07C 50/30 (2006.01); C07C 59/347 (2006.01); C07C 59/82 (2006.01); C07C 59/84 (2006.01); C07C 59/90 (2006.01); C07C 69/716 (2006.01); C07C 69/738 (2006.01); C07C 235/74 (2006.01); C07C 261/04 (2006.01); C07C 309/07 (2006.01); C07C 309/24 (2006.01); C07D 233/72 (2006.01); C07D 233/84 (2006.01); C07D 233/86 (2006.01); C07D 257/04 (2006.01); C07D 261/12 (2006.01); C07D 305/12 (2006.01); C07D 307/33 (2006.01); C07D 309/12 (2006.01); C07D 309/30 (2006.01); C07D 309/40 (2006.01); C07F 9/09 (2006.01); C07F 9/24 (2006.01); C07F 9/44 (2006.01);
U.S. Cl.
CPC ...
C07C 59/353 (2013.01); C07C 49/17 (2013.01); C07C 49/185 (2013.01); C07C 49/215 (2013.01); C07C 49/245 (2013.01); C07C 49/258 (2013.01); C07C 49/507 (2013.01); C07C 49/723 (2013.01); C07C 49/743 (2013.01); C07C 49/747 (2013.01); C07C 49/784 (2013.01); C07C 49/82 (2013.01); C07C 49/86 (2013.01); C07C 50/30 (2013.01); C07C 59/347 (2013.01); C07C 59/82 (2013.01); C07C 59/84 (2013.01); C07C 59/90 (2013.01); C07C 69/716 (2013.01); C07C 69/738 (2013.01); C07C 235/74 (2013.01); C07C 261/04 (2013.01); C07C 309/07 (2013.01); C07C 309/24 (2013.01); C07D 233/72 (2013.01); C07D 233/84 (2013.01); C07D 233/86 (2013.01); C07D 257/04 (2013.01); C07D 261/12 (2013.01); C07D 305/12 (2013.01); C07D 307/33 (2013.01); C07D 309/12 (2013.01); C07D 309/30 (2013.01); C07D 309/40 (2013.01); C07F 9/093 (2013.01); C07F 9/2425 (2013.01); C07F 9/4423 (2013.01); C07C 2101/08 (2013.01); C07C 2101/10 (2013.01); C07C 2101/14 (2013.01); C07C 2101/16 (2013.01);
Abstract

The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.

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