The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2015
Filed:
Sep. 05, 2008
Ahmad Malkawi, Lexington, KY (US);
Abeer M. Al-ghananeem, Lexington, KY (US);
Patrick Deluca, Lexington, KY (US);
George A. Digenis, Louisville, KY (US);
Ahmad Malkawi, Lexington, KY (US);
Abeer M. Al-Ghananeem, Lexington, KY (US);
Patrick DeLuca, Lexington, KY (US);
George A. Digenis, Louisville, KY (US);
US WorldMeds LLC, Louisville, KY (US);
Abstract
The present invention provides for methods of using tert-butyl alcohol (TBA) co-solvent systems in the formulation and production of a pharmaceutical agent with low solubility. The present invention also provides for pharmaceutical compositions made using the novel co-solvent system. In one embodiment, the invention provides for a method of making dantrolene sodium (DS) formulation for intravenous use (DS-IV). This instantaneous reconstitution of the DS-IV product constitutes a significant improvement in the pharmacotherapy of patients undergoing malignant hyperthermia during surgery.