The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2015

Filed:

Dec. 13, 2005
Applicants:

Sara Zaknoen, Hoboken, NJ (US);

Margaret MA Woo, Raritan, NJ (US);

Richard William Versace, Wanaque, NJ (US);

Claudio Pisano, Aprilia, IT;

Loredana Vesci, Rome, IT;

Inventors:

Sara Zaknoen, Hoboken, NJ (US);

Margaret Ma Woo, Raritan, NJ (US);

Richard William Versace, Wanaque, NJ (US);

Claudio Pisano, Aprilia, IT;

Loredana Vesci, Rome, IT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/47 (2006.01); A61K 31/282 (2006.01); A61K 33/24 (2006.01); A61K 39/395 (2006.01); A61K 31/427 (2006.01); A61K 31/53 (2006.01); A61K 31/555 (2006.01); A61K 31/4745 (2006.01); A61K 31/337 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 31/282 (2013.01); A61K 33/24 (2013.01); A61K 39/395 (2013.01); A61K 31/427 (2013.01); A61K 31/53 (2013.01); A61K 31/555 (2013.01); A61K 31/4745 (2013.01); A61K 31/337 (2013.01);
Abstract

A combination therapy for treating patients suffering from proliferative diseases or diseases associated with persistent angiogenesis is disclosed. The patient is treated with a camptothecin derivative and one or more chemotherapeutic agents selected from a microtubule active agent; an alkylating agent; an anti-neoplastic anti-metabolite; a platin compound; a topoisomerase II inhibitor; a VEGF inhibitor; a tyrosine kinase inhibitor; an EGFR kinase inhibitor; an mTOR kinase inhibitor; an insulin-like growth factor I inhibitor; a Raf kinase inhibitor; a monoclonal antibody; a proteasome inhibitor; a HDAC inhibitor; and ionizing radiation.


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