The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 10, 2015

Filed:

Aug. 01, 2011
Applicants:

Bradley P. Kropp, Edmond, OK (US);

Hsueh-kung Lin, Edmond, OK (US);

Fadee Mandelek, Oklahoma City, OK (US);

Brian P. Grady, Norman, OK (US);

Inventors:

Bradley P. Kropp, Edmond, OK (US);

Hsueh-Kung Lin, Edmond, OK (US);

Fadee Mandelek, Oklahoma City, OK (US);

Brian P. Grady, Norman, OK (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/56 (2006.01); A61F 2/04 (2013.01); A61K 35/38 (2006.01); A61F 2/02 (2006.01); A61L 27/36 (2006.01); A61L 27/38 (2006.01); C12N 5/071 (2010.01); A61K 35/12 (2006.01);
U.S. Cl.
CPC ...
A61F 2/04 (2013.01); A61F 2/02 (2013.01); A61K 35/38 (2013.01); A61L 27/3629 (2013.01); A61L 27/3679 (2013.01); A61L 27/3813 (2013.01); A61L 27/3826 (2013.01); A61L 27/383 (2013.01); A61L 27/3882 (2013.01); A61L 27/3886 (2013.01); C12N 5/0685 (2013.01); A61K 35/12 (2013.01); A61L 2430/22 (2013.01); C12N 2502/1347 (2013.01); C12N 2531/00 (2013.01); C12N 2533/40 (2013.01); C12N 2533/92 (2013.01); A61L 2400/12 (2013.01);
Abstract

A tissue graft composition is described herein that includes a segment of small intestinal submucosa having at least one nanoparticle incorporated therein such that the permeability of the segment of small intestinal submucosa is altered, thereby providing the segment of small intestinal submucosa with a more substantially uniform structure for cell migration and proliferation. The tissue graft composition may further comprise at least one macromolecule incorporated into the nanoparticle. The tissue graft composition may be utilized in seeded or unseeded methods of tissue repair.


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