The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 10, 2015
Filed:
Dec. 07, 2012
Applicant:
Ikaria Development Subsidiary One Llc, Hampton, NJ (US);
Inventors:
Fuqiang Ruan, Bellevue, WA (US);
Thomas L. Deckwerth, Seattle, WA (US);
Martin D. Meglasson, Bloomsbury, NJ (US);
Assignee:
Bellerophon BCM LLC, Hampton, NJ (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 51/00 (2006.01); A61M 36/14 (2006.01); C07D 255/02 (2006.01); A61K 51/06 (2006.01); C07B 59/00 (2006.01); C07F 1/08 (2006.01); C07F 5/00 (2006.01); C08B 37/00 (2006.01);
U.S. Cl.
CPC ...
C07D 255/02 (2013.01); A61K 51/065 (2013.01); C07B 59/002 (2013.01); C07F 1/08 (2013.01); C07F 5/003 (2013.01); C08B 37/0084 (2013.01);
Abstract
Described are bifunctional NOTA-based derivatives capable of conjugating with alginate and with metal ions, as well as NOTA-alginate conjugates which can be labeled with stable or radioactive metal ions. Also described are conjugation methods of the bifunctional NOTA-based linker with alginate, and methods of using radiometal-labeled NOTA-alginate conjugates or other radio-labeled alginate conjugates as imaging reagents.