The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2015

Filed:

Mar. 05, 2013
Applicants:

Yingzhi BI, Plainsboro, NJ (US);

Kenneth Gordon Carson, Princeton, NJ (US);

Giovanni Cianchetta, Waltham, MA (US);

Michael Alan Green, Easton, PA (US);

Godwin Kumi, Belle Mead, NJ (US);

Zhi Liang, Lawrenceville, NJ (US);

Ying Jade Liu, Lawrenceville, NJ (US);

Alan Main, Far Hills, NJ (US);

Yulian Zhang, Acton, MA (US);

Gregory Glenn Zipp, Robbinsville, NJ (US);

Inventors:

Yingzhi Bi, Plainsboro, NJ (US);

Kenneth Gordon Carson, Princeton, NJ (US);

Giovanni Cianchetta, Waltham, MA (US);

Michael Alan Green, Easton, PA (US);

Godwin Kumi, Belle Mead, NJ (US);

Zhi Liang, Lawrenceville, NJ (US);

Ying Jade Liu, Lawrenceville, NJ (US);

Alan Main, Far Hills, NJ (US);

Yulian Zhang, Acton, MA (US);

Gregory Glenn Zipp, Robbinsville, NJ (US);

Assignee:

Lexicon Pharmaceuticals, Inc., The Woodlands, TX (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 241/04 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 487/04 (2006.01); A61K 31/5025 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 241/04 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); A61K 31/5025 (2013.01);
Abstract

Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R, Rand Rare defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.


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