IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8969353 B1

PDFFull Text
Date of Patent:
Mar. 03, 2015

Filed:

Nov. 06, 2009

Aminoalcohol lipidoids and uses thereof

Applicants:

Kerry Peter Mahon, Cambridge, MA (US);

Kevin Thomas Love, Cambridge, MA (US);

Christopher G. Levins, Somerville, MA (US);

Kathryn Ann Whitehead, Somerville, MA (US);

Robert S. Langer, Newton, MA (US);

Daniel Griffith Anderson, Sudbury, MA (US);

Inventors:

Kerry Peter Mahon, Cambridge, MA (US);

Kevin Thomas Love, Cambridge, MA (US);

Christopher G. Levins, Somerville, MA (US);

Kathryn Ann Whitehead, Somerville, MA (US);

Robert S. Langer, Newton, MA (US);

Daniel Griffith Anderson, Sudbury, MA (US);

Assignee:

Massachusetts Institute of Technology, Cambridge, MA (US);

Attorneys:

Wolf, Greenfield & Sacks, P.C.

C. Hunter Baker

Primary Examiner:

Golam M M Shameem

Int. Cl.
CPC ...
A61K 31/495 (2006.01); C07D 241/04 (2006.01); A61K 9/127 (2006.01); A61K 47/16 (2006.01); C07C 215/14 (2006.01); C12N 15/11 (2006.01); C07C 217/08 (2006.01); A61K 9/51 (2006.01); C12N 15/88 (2006.01); C07D 295/13 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C07D 295/13 (2013.01); A61K 9/1271 (2013.01); A61K 47/16 (2013.01); C12N 2310/3515 (2013.01); C07C 215/14 (2013.01); C12N 15/111 (2013.01); C12N 2320/32 (2013.01); B01J 2531/845 (2013.01); C07C 217/08 (2013.01); A61K 9/5123 (2013.01); C12N 2310/14 (2013.01); C12N 15/88 (2013.01); A61K 48/0025 (2013.01); B01J 2531/0252 (2013.01);
Abstract

Aminoalcohol lipidoids are prepared by reacting an amine with an epoxide-terminated compound are described. Methods of preparing aminoalcohol lipidoids from commercially available starting materials are also provided. Aminoalcohol lipidoids may be prepared from racemic or stereochemically pure epoxides. Aminoalcohol lipidoids or salts forms thereof are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the amino moiety of these aminoalcohol lipidoid compounds, they are particularly suited for the delivery of polynucleotides. Complexes, micelles, liposomes or particles containing the inventive lipidoids and polynucleotide have been prepared. The inventive lipidoids may also be used in preparing microparticles for drug delivery. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.

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