The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2015
Filed:
Oct. 05, 2009
Applicants:
Martin Bergmann, Hamburg, DE;
Joerg Huelsken, Denges, CH;
Walter Birchmeier, Schwanebeck, DE;
Makoto Mark Taketo, Kyoto, JP;
Inventors:
Martin Bergmann, Hamburg, DE;
Joerg Huelsken, Denges, CH;
Walter Birchmeier, Schwanebeck, DE;
Makoto Mark Taketo, Kyoto, JP;
Assignee:
Max-Delbrueck-Centrum fuer Molekulare Medizin, Berlin, DE;
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 31/203 (2006.01); A01K 67/027 (2006.01); A61K 31/405 (2006.01); A61K 31/415 (2006.01); A61K 31/711 (2006.01); A61K 38/17 (2006.01); C07K 14/47 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 31/203 (2013.01); A01K 67/0276 (2013.01); A61K 31/405 (2013.01); A61K 31/415 (2013.01); A61K 31/711 (2013.01); A61K 38/1709 (2013.01); C07K 14/4702 (2013.01); C12N 15/8509 (2013.01); A01K 2217/075 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); A61K 48/00 (2013.01);
Abstract
Disclosed is the use of inhibitors of β-catenin expression or activity or modulators downregulating β-catenin expression or activity for the treatment of cardiovascular diseases or disorders and their use in the treatment of cardiovascular diseases and disorders, such as heart failure syndrome. The use of those agents resulted in particular in cardiomyocyte differentiation of endogenous cardiac stem cells.