The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2015

Filed:

Dec. 31, 2013
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Rockville, MD (US);

Inventors:

Dennis J. Kopecko, Silver Spring, MD (US);

De-Qi Xu, Columbia, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/02 (2006.01); A61K 39/116 (2006.01); A61K 39/112 (2006.01); C07K 14/25 (2006.01); C12N 15/52 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0283 (2013.01); A61K 48/00 (2013.01); A61K 2039/522 (2013.01); A61K 2039/523 (2013.01); C07K 14/25 (2013.01); C12N 15/52 (2013.01);
Abstract

The invention relates toTy21a comprising core-linkedserotype 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2 and species homologs thereof; b) DNA encodingserotype 1 polypeptides encoded by any one of SEQ ID NOs: 1 and 2, and species homologs thereof; and c) DNA encoding a O antigen biosynthesis gene product that hybridizes under moderately stringent conditions to the DNA of (a) or (b); and related sequences, compositions of matter, vaccines, methods of using, and methods of making.


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