The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 03, 2015
Filed:
Mar. 30, 2007
Chuan-yuan LI, Englewood, CO (US);
Fang LI, Greenwood Village, CO (US);
Pierre Sonveaux, Ottignies-Louvain-la-Neuve, BE;
Mark W. Dewhirst, Durham, NC (US);
Chuan-Yuan Li, Englewood, CO (US);
Fang Li, Greenwood Village, CO (US);
Pierre Sonveaux, Ottignies-Louvain-la-Neuve, BE;
Mark W. Dewhirst, Durham, NC (US);
Duke University, Durham, NC (US);
Abstract
The presently disclosed subject matter generally relates to methods and compositions for inhibiting the expression and/or activation of hypoxia-inducible factor 1 (HIF-1) genes in a hypoxic cell. More particularly, the methods disclosed herein relate to inhibition of HIF-1 activation in a cell, increasing sensitivity of a tumor cell to radiation and/or chemotherapy, delaying tumor growth, inhibiting tumor blood vessel growth, inhibiting inflammatory responses in a cell through the use of compositions that prevent the nitrosylation of HIF-1, and methods for screening for new inhibitors of HIF-1 activiation. Additionally, the compositions disclosed herein relate to compositions that can be employed in, and are identified by, the disclosed methods.