The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Mar. 03, 2015

Filed:

Jul. 30, 2012
Applicants:

Ikuo Omura, Okayama, JP;

Zhen Yu Jin, Okayama, JP;

Shuzo Yamashita, Okayama, JP;

Hiroo Iwata, Kyoto, JP;

Akira Mochizuki, Numazu, JP;

Inventors:

Ikuo Omura, Okayama, JP;

Zhen Yu Jin, Okayama, JP;

Shuzo Yamashita, Okayama, JP;

Hiroo Iwata, Kyoto, JP;

Akira Mochizuki, Numazu, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61F 2/82 (2013.01); A61F 2/00 (2006.01); A61L 33/00 (2006.01); A61F 2/915 (2013.01); A61K 9/00 (2006.01); A61L 31/10 (2006.01); A61L 31/16 (2006.01); A61F 2/91 (2013.01);
U.S. Cl.
CPC ...
A61F 2/82 (2013.01); A61F 2/915 (2013.01); A61K 9/0024 (2013.01); A61L 31/10 (2013.01); A61L 31/16 (2013.01); A61F 2/91 (2013.01); A61F 2002/91541 (2013.01); A61F 2250/0067 (2013.01); A61L 2300/416 (2013.01); A61L 2300/608 (2013.01); A61L 2420/08 (2013.01);
Abstract

A method of inhibiting vascular intimal hyperplasia including: placing a stent within a blood vessel, the stent having a stent body of a cylindrical configuration having outer and inner surfaces with a diamond-like thin film coated on the surfaces, a first coated layer coating at least the outer surface of the stent body, the first coated layer being prepared of a first composition comprising a biodegradable polymer and a vascular intimal hyperplasia inhibitor of a kind, comprising argatroban, which does not inhibit proliferation of endothelial cells, the weight composition ratio of the polymer to the vascular intimal hyperplasia inhibitor being within the range of 8:2 to 7:3, and a second coated layer; and causing argatroban to be released from the stent to thereby inhibit the vascular intimal hyperplasia without inhibiting proliferation of endothelial cells.


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