IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8962834 B1

PDFFull Text
Date of Patent:
Feb. 24, 2015

Filed:

Jan. 25, 2013

Modulators of amyloid beta

Applicant:

Hoffmann-la Roche Inc., Nutley, NJ (US);

Inventors:

Karlheinz Baumann, Efringen-Kirchen, DE;

Alexander Flohr, Loerrach, DE;

Erwin Goetschi, Reinach BL, CH;

Helmut Jacobsen, Schopfheim, DE;

Synese Jolidon, Blauen, CH;

Thomas Luebbers, Loerrach, DE;

Assignee:

Hoffmann-La Roche Inc., Nutley, NJ (US);

Attorney:
Primary Examiner:

James O Wilson

Assistant Examiner:

Cecilia M Jaisle

Int. Cl.
CPC ...
C07D 403/12 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/14 (2006.01); C07D 409/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 405/14 (2006.01); C07D 417/14 (2006.01); A61P 25/28 (2006.01);
U.S. Cl.
CPC ...
C07D 403/12 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/14 (2013.01); C07D 409/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 405/14 (2013.01); C07D 417/14 (2013.01);
Abstract

The invention relates to compounds of formula wherein the substituents are as described in claim. Compounds of formula I are modulators for amyloid beta and thus, they may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.

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