The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2015
Filed:
Feb. 20, 2009
Bernhard K. Mueller, Neustadt, DE;
Martin Schmidt, Bensheim, DE;
Eve Barlow, Wellesley, MA (US);
Mary Leddy, North Attleborough, MA (US);
Chung-ming Hsieh, Newton, MA (US);
Philip Bardwell, Boston, MA (US);
Bernhard K. Mueller, Neustadt, DE;
Martin Schmidt, Bensheim, DE;
Eve Barlow, Wellesley, MA (US);
Mary Leddy, North Attleborough, MA (US);
Chung-Ming Hsieh, Newton, MA (US);
Philip Bardwell, Boston, MA (US);
AbbVie Deutschland GmbH & Co. KG, Wiesbaden, DE;
AbbVie Inc., North Chicago, IL (US);
Abstract
The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize RGM A protein. Specifically, these antibodies have the ability to inhibit the binding of RGM A to its receptor and/or coreceptors. These antibodies or portions thereof of the invention are useful for detecting RGM A and for inhibiting RGM A activity, for example in a human suffering from a disorder including but nor limited to multiple sclerosis, mammalian brain trauma, spinal cord injury, stroke, neurodegenerative diseases, and schizophrenia.