The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 2015

Filed:

Nov. 14, 2012
Applicants:

Maastricht University, Maastricht, NL;

Academic Hospital Maastricht, Maastricht, NL;

Inventors:

Peter Joseph Emans, Maastricht, NL;

Lodewijk Willem Van Rhijn, Maastricht, NL;

Tim Johannes Maria Welting, Klimmen, NL;

Mike De Leeuw, Mheer, NL;

Assignees:

Maastricht University, Maastricht, NL;

Academic Hospital Maastricht, Maastricht, NL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/42 (2006.01); A61K 31/40 (2006.01); A61K 9/00 (2006.01); A61K 31/728 (2006.01); A61L 27/52 (2006.01); A61L 27/54 (2006.01); A61K 38/20 (2006.01);
U.S. Cl.
CPC ...
A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 31/42 (2013.01); A61K 31/728 (2013.01); A61L 27/52 (2013.01); A61L 27/54 (2013.01); A61K 38/2013 (2013.01); A61L 2300/252 (2013.01); A61L 2300/414 (2013.01); A61L 2300/426 (2013.01); A61L 2300/432 (2013.01); A61L 2300/452 (2013.01);
Abstract

The invention is in the field of methods for medical treatment. It provides an improved method for repairing damaged cartilage and/or preventing cartilage degeneration in tissue, in particular in a joint by administering a pharmaceutically active agent directly into the fat pad of a joint. The pharmaceutically active agent is preferably selected from the group consisting of agents that stimulate chondrogenic differentiation and/or cartilage matrix synthesis; agents that inhibit osteogenesis and/or hypertrophy, anti-inflammatory agents, agents that inhibit apoptosis of chondrocytes, agents that inhibit senescence of chondrocytes and agents that enhance lubrication of a joint.


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