The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2015
Filed:
Apr. 27, 2012
K. Raja Reddy, San Diego, CA (US);
Jeff Stebbins, San Diego, CA (US);
Serge H. Boyer, San Diego, CA (US);
Mark D. Erion, Del Mar, CA (US);
Scott J. Hecker, Del Mar, CA (US);
Nicholas Brian Raffaele, San Diego, CA (US);
Brett C. Bookser, San Diego, CA (US);
Venkat Reddy Mali, Cupertino, CA (US);
K. Raja Reddy, San Diego, CA (US);
Jeff Stebbins, San Diego, CA (US);
Serge H. Boyer, San Diego, CA (US);
Mark D. Erion, Del Mar, CA (US);
Scott J. Hecker, Del Mar, CA (US);
Nicholas Brian Raffaele, San Diego, CA (US);
Brett C. Bookser, San Diego, CA (US);
Venkat Reddy Mali, Cupertino, CA (US);
Metabasis Therapeutics, Inc., La Jolla, CA (US);
Abstract
The invention pertains to the use of fused bicyclo heterocyclic adducts of thiohdroxy pridines or primidines as diacylglycerol O-acyltransferase 1 DGAT-1 inhibitors to treat hyperlipidiemias and various diseases and disorders associated therewith. Other conditions also can be ameliorated or avoided, such as high postprandial triglycerides or diet-related hypertriglyceridemia, cardiovascular risk associated with excessive triglycerides, and insulin resistance/glucose intolerance in overweight patients, those with diabetes or other glucose metabolic disorders such as Syndrome X and/or polycystic ovary disease.