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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8962609 B1

PDFFull Text
Date of Patent:
Feb. 24, 2015

Filed:

Jul. 18, 2011

Pyrimidine compounds as inhibitors of protein kinases ikk epsilon and/or tbk-1, processes for their preparation, and pharmaceutical compositions containing them

Applicants:

Trevor Robert Perrior, Cambridge, GB;

Gary Karl Newton, Cambridge, GB;

Mark Richard Stewart, Cambridge, GB;

Rehan Aqil, Cambridge, GB;

Inventors:

Trevor Robert Perrior, Cambridge, GB;

Gary Karl Newton, Cambridge, GB;

Mark Richard Stewart, Cambridge, GB;

Rehan Aqil, Cambridge, GB;

Assignee:

Domainex Limited, , GB;

Attorney:

Hahn Loeser & Parks LLP

Primary Examiner:

James O Wilson

Assistant Examiner:

Ebenezer O Sackey

Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/535 (2006.01); A61K 31/497 (2006.01); A61K 31/505 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 403/10 (2006.01); C07D 417/10 (2006.01); C07D 403/14 (2006.01); C07D 239/42 (2006.01); C07D 403/12 (2006.01); C07D 417/14 (2006.01);
U.S. Cl.
CPC ...
C07D 403/10 (2013.01); C07D 239/42 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01);
Abstract

C Compounds of the general formula (I) and salts thereof are useful in the treatment of diseases associated with aberrant activity of the protein kinases IKKε and/or TBK-1: in which: Rrepresents an aliphatic heterocyclyl group having 4, 5, 6 or 7 ring atoms, bonded to the phenyl group shown in formula I through a ring nitrogen atom, and optionally substituted by one or more substituents defined in the Specification; Rrepresents a phenyl or heteroaryl group which is optionally substituted by one or more substituents defined in the Specification; and each of Rand Rindependently represents a hydrogen atom or a Calkyl group.

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