The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 2015

Filed:

Apr. 11, 2011
Applicants:

Laurence E. Burgess, Boulder, CO (US);

Mark Laurence Boys, Boulder, CO (US);

Robert D. Groneberg, Boulder, CO (US);

Darren M. Harvey, Acton, MA (US);

Timothy Kercher, Boulder, CO (US);

Christopher F. Kraser, Boulder, CO (US);

Ellen Laird, Boulder, CO (US);

Eugene Tarlton, Lafayette, CO (US);

Qian Zhao, Louisville, CO (US);

Lily Huang, Austin, TX (US);

Inventors:

Laurence E. Burgess, Boulder, CO (US);

Mark Laurence Boys, Boulder, CO (US);

Robert D. Groneberg, Boulder, CO (US);

Darren M. Harvey, Acton, MA (US);

Timothy Kercher, Boulder, CO (US);

Christopher F. Kraser, Boulder, CO (US);

Ellen Laird, Boulder, CO (US);

Eugene Tarlton, Lafayette, CO (US);

Qian Zhao, Louisville, CO (US);

Lily Huang, Austin, TX (US);

Assignee:

Array BioPharma Inc., Boulder, CO (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/519 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); A61P 37/06 (2006.01); C07D 498/04 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07D 498/04 (2013.01);
Abstract

Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R, R, R, R, R, R, R, Xand Xhave the meanings given in the specification, are inhibitors of one or more JAK kinases and are useful in the treatment of autoimmune diseases, inflammatory diseases, rejection of transplanted organs, tissues and cells, as well as hematologic disorders and malignancies and their co-morbidities.


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