The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 2015

Filed:

Dec. 10, 2009
Applicants:

David Alan Zacharias, St. Augustine, FL (US);

Sonia Lobo Planey, Scranton, PA (US);

Inventors:

David Alan Zacharias, St. Augustine, FL (US);

Sonia Lobo Planey, Scranton, PA (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 21/77 (2006.01); C12M 3/00 (2006.01); G01N 21/75 (2006.01); G01N 33/50 (2006.01); C07K 9/00 (2006.01); C07K 14/705 (2006.01); C12Q 1/68 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5091 (2013.01); C07K 9/005 (2013.01); C07K 14/705 (2013.01); C12Q 1/6897 (2013.01); G01N 33/6893 (2013.01); G01N 2333/4728 (2013.01); G01N 2800/34 (2013.01);
Abstract

An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.


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