The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2015
Filed:
Jul. 12, 2012
Theodorus Hendrikus Jacobus Kwaks, Amsterdam, NL;
David Adrianus Theodorus Maria Zuijdgeest, The Hague, NL;
Ronald Vogels, Linschoten, NL;
Robert Heinz Edward Friesen, Leiden, NL;
Theodorus Hendrikus Jacobus Kwaks, Amsterdam, NL;
David Adrianus Theodorus Maria Zuijdgeest, The Hague, NL;
Ronald Vogels, Linschoten, NL;
Robert Heinz Edward Friesen, Leiden, NL;
Crucell Holland B.V., Leiden, NL;
Abstract
The present disclosure relates to binding molecules, such as human monoclonal antibodies, that bind to an epitope in the stem region of hemagglutinin of influenza A viruses of phylogenetic group 1 and group 2, as well as influenza B viruses, and have a broad neutralizing activity against such influenza viruses. The disclosure provides nucleic acid molecules encoding the binding molecules, their sequences and compositions comprising the binding molecules. The binding molecules can be used in the diagnosis, prophylaxis and/or treatment of influenza A viruses of phylogenetic groups 1 and 2, as well as influenza B viruses.