The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 24, 2015

Filed:

Jun. 27, 2013
Applicant:

Hasumi International Research Foundation, Washington, DC (US);

Inventor:

Kenichiro Hasumi, Suginami-Ku Tokyo, JP;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 63/00 (2006.01); A61K 45/00 (2006.01); A61K 47/00 (2006.01); A61K 39/395 (2006.01); C12N 5/0786 (2010.01); C12N 5/0783 (2010.01); C07K 16/24 (2006.01);
U.S. Cl.
CPC ...
A61K 39/3955 (2013.01); A61K 35/15 (2013.01); A61K 35/17 (2013.01); C12N 5/0645 (2013.01); C12N 5/0638 (2013.01); C12N 5/0646 (2013.01); C07K 16/241 (2013.01);
Abstract

The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to, coincident with, or following introducing intratumorally the cytotoxic T lymphocyte and/or NKT cells, introducing intratumorally anti-TNF and/or anti-IL-10 to the patient. The cytotoxic T lymphocyte and/or NKT cells can be induced by the intratumoral introduction of immature dendritic cells to the patient. This therapy of the invention can be effective to regress, reduce or eliminate tumor cells in tumor tissue of the patients in the absence of radiation therapy.


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