The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2015
Filed:
Apr. 15, 2011
Seong Jun Yoon, Seoul, KR;
Soo Youn Jun, Seoul, KP;
An Sung Kwon, Gwangju, KR;
Sang Hyeon Kang, Seoul, KR;
Yong Yeon Jeong, Gwangju, KR;
IN Kyu Park, Gwangju, KR;
Chong Su Cho, Seoul, KR;
You Kyoung Kim, Seoul, KR;
Won Jong Kim, Gyeongsangbuk-Do, KR;
Ran Namgung, Gyeongsangbuk-Do, KR;
Seong Jun Yoon, Seoul, KR;
Soo Youn Jun, Seoul, KP;
An Sung Kwon, Gwangju, KR;
Sang Hyeon Kang, Seoul, KR;
Yong Yeon Jeong, Gwangju, KR;
In Kyu Park, Gwangju, KR;
Chong Su Cho, Seoul, KR;
You Kyoung Kim, Seoul, KR;
Won Jong Kim, Gyeongsangbuk-Do, KR;
Ran Namgung, Gyeongsangbuk-Do, KR;
Intron Biotechnology, Inc., , KR;
Abstract
The present invention relates to a magnetic resonance imaging (MRI) contrast agent coated with carboxylated mannan, particularly a carboxylated mannan coated superparamagnetic MRI contrast agent specifically targeting antigen presenting cells and having excellent in vivo stability, and a method for producing the same. The MRI contrast agent coated with carboxylated mannan of the present invention can provide excellent in vivo stability and biocompatibility owing to its high surface negative charge, and can be introduced specifically into antigen presenting cells owing to mannose of mannan, so as to visualize the antigen presenting cells and the tissue containing the antigen presenting cells in MRI.