The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 2015
Filed:
May. 09, 2012
Yun-ming Wang, Hsinchu, TW;
Gin-chung Liu, Hsinchu, TW;
Chiao-yun Chen, Hsinchu, TW;
Teng-wen LI, Hsinchu, TW;
Yun-Ming Wang, Hsinchu, TW;
Gin-Chung Liu, Hsinchu, TW;
Chiao-Yun Chen, Hsinchu, TW;
Teng-Wen Li, Hsinchu, TW;
National Chiao Tung University, Hsinchu, TW;
Abstract
A ligand and a metal complex having the ligand are provided. The ligand and a paramagnetic metal ion form a metal complex with high stability, high relaxivity and high biocompatibility. The metal complex of the present invention is applicable to the preparation of MRI contrast agents for detecting atherosclerosis. The MRI contrast agent includes a peptide sequence specific to a matrix metalloprotease, and can be recognized by a pathological thrombocyte to target a specific site, so as to enhance the imaging contrast.