The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Apr. 18, 2008
Taifo Mahmud, Covallis, OR (US);
Takuya Ito, Tokushima, JP;
Patricia M. Flatt, Corvallis, OR (US);
Niran Roongsawang, Corvallis, OR (US);
Norifumi Shirasaka, Corvallis, OR (US);
Taifo Mahmud, Covallis, OR (US);
Takuya Ito, Tokushima, JP;
Patricia M. Flatt, Corvallis, OR (US);
Niran Roongsawang, Corvallis, OR (US);
Norifumi Shirasaka, Corvallis, OR (US);
Abstract
This disclosure describes the molecular cloning of a pactamycin biosynthetic gene cluster fromATCC 27456, characterization of individual genes in the gene cluster and the proteins encoded thereby as well as uses thereof. The pactamycin gene cluster is located within an 86.35 kilobases genetic locus and includes 53 open reading frames, 26 of which are considered to be the core cluster directly involved in the biosynthesis of pactamycin. The present disclosure also relates to the use of the pactamycin biosynthetic genes located within the identified gene cluster for drug design and development purposes, including the development of pactamycin analogs that are more efficacious and less toxic. Also provided are drugs and antibiotics so produced, as well as methods of their use.