The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Oct. 14, 2011
Meinrad Brenner, Steg, CH;
Erick M. Carreira, Zurich, CH;
Nicka Chinkov, Haifa, IL;
Miriam Lorenzi, Rheinfelden, CH;
Aleksander Warm, Arbaz, CH;
Lothar Zimmermann, Brigerbad, CH;
Meinrad Brenner, Steg, CH;
Erick M. Carreira, Zurich, CH;
Nicka Chinkov, Haifa, IL;
Miriam Lorenzi, Rheinfelden, CH;
Aleksander Warm, Arbaz, CH;
Lothar Zimmermann, Brigerbad, CH;
Lonza Ltd., Visp, CH;
Abstract
The invention is directed to a process for the preparation of a cyclic carbamate starting with a chiral propargylic alcohol and/or a suitable salt thereof, which is reacted with a cyclization agent selected from phosgene, diphosgene, triphosgene and mixtures thereof, and in that the reaction is carried out in the presence of an aqueous base, and a water-immiscible organic solvent, said organic solvent mainly comprising at least one compound selected from C-alkyl C-carboxylates and mixtures of at least one C-alkyl C-carboxylate with at least one C-alkane. Another aspect of the invention is directed to a process for the synthesis of said cyclic carbamate starting described above, wherein also a process for the preparation of the chiral propargylic alcohol is provided.