The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Dec. 01, 2006
Sachdev S. Sidhu, San Francisco, CA (US);
Sara C. Birtalan, Menlo Park, CA (US);
Frederic A. Fellouse, Toronto, CA;
Sachdev S. Sidhu, San Francisco, CA (US);
Sara C. Birtalan, Menlo Park, CA (US);
Frederic A. Fellouse, Toronto, CA;
Genentech, Inc., South San Francisco, CA (US);
Abstract
The invention provides antibodies or antigen binding fragments thereof to DR5 and HER-2. The antibodies and/or antigen binding fragments thereof comprise variant CDRs comprising highly restricted amino acid sequence diversity. The invention also provides these polypeptides as fusion polypeptides to heterologous polypeptides such as at least a portion of phage or viral coat proteins, tags and linkers. In addition, compositions and methods of use for treatment of cancer and immune related conditions are provided.