The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 17, 2015
Filed:
Nov. 18, 2011
Ana Elena Minatti, Santa Monica, CA (US);
Oleg Epstein, Belmont, MA (US);
Ryan White, Somerville, MA (US);
Matthew Weiss, Boston, MA (US);
Wenge Zhong, Thousand Oaks, CA (US);
Jonathan D. Low, Tarzana, CA (US);
Ana Elena Minatti, Santa Monica, CA (US);
Oleg Epstein, Belmont, MA (US);
Ryan White, Somerville, MA (US);
Matthew Weiss, Boston, MA (US);
Wenge Zhong, Thousand Oaks, CA (US);
Jonathan D. Low, Tarzana, CA (US);
Amgen Inc., Thousand Oaks, CA (US);
Abstract
The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A, A, A, A, A, A, L, R, R, R, W and Y of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, sub-Formula embodiments of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulae I-III.